Thermoresponsive Poly ( <i>N</i> ‐Isopropylacrylamide)/Polycaprolacton Nanofibrous Scaffolds for Controlled Release of Antibiotics

نویسندگان

چکیده

Smart antibacterial materials capable of releasing antibiotic drugs upon exposure to external triggers are highly desired for various medical applications. Herein, the fabrication thermosensitive drug-loaded core−shell nanofibers using electrospinning technique combined with in situ UV photopolymerization is reported on. The method used shaping core structure comprising biodegradable polymer polycaprolactone (PCL). PCL fibers coated temperature-responsive poly-N-isopropylacrylamide (PNIPAM) via a process that allows precisely control shell thickness as verified by transmission electron microscope (TEM) analysis. temperature-dependent switchable wettability prepared investigated and visualized though water contact angle measurements below above lower critical solution temperature. Loading drug doxycycline hyclate (Doxy) results drug-encapsulating fiber meshes allow diffusion molecules through PNIPAM manner. activity examined Gram-negative Escherichia coli (E. coli) well Gram-positive Staphylococcus aureus (S. aureus) bacteria. demonstrate high suitability biocompatible electrospun PCL/PNIPAM carriers temperature-sensitive release behavior.

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ژورنال

عنوان ژورنال: Advanced Engineering Materials

سال: 2021

ISSN: ['1527-2648', '1438-1656']

DOI: https://doi.org/10.1002/adem.202100221